Mackinac Financial (MFNC) $21.16 +60%

Mackinac screamed 60% higher on news that Nicolet Bancshares (NCBS) would acquire them. The 80% stock and 20% cash deal equates to $23.31 per share. Mackinac has assets in excess of $1.5 billion, is best known for mBank has 28 branch locations; ten in the Upper Peninsula, ten in the Northern Lower Peninsula, one in Oakland County, Michigan, and seven in Northern Wisconsin. News

Novocure (NVCR) $197 +49%

Novocure surged 81% premarket and closed up $65 or 49%. The surge came after receiving the go-ahead from an independent data-monitoring committee (“DMC”) on Apr 13 for the company’s LUNAR trial of tumor-treating fields in non-small cell lung cancer. The DMC found no evidence of increased systemic toxicity, and accordingly recommended the company to test 276 patients with 12 months of follow-up time instead of 534 patients with 18 months of follow-up.News

VTVT Therapeutics (VTVT) $3.44 +33%

“Vity-Vity” proved the critics wrong when the FDA granted VTVT Breakthrough Therapy designation for TTP399 as an adjunctive therapy to insulin for the treatment of type 1 diabetes. TTP399 is a novel, oral, investigational once-daily glucokinase activator. After a difficult 2019-2020, VTVT is looking strong,up 84%YTD. Breakthrough Therapy designation is based on FDA’s determination that preliminary clinical evidence indicates that an investigational therapy may demonstrate substantial improvement on one or more significant endpoints relative to available therapies for a serious or life-threatening condition.News

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